下一代疗法

小分子

We have a long history of discovering and developing orally delivered small molecule medicines by harnessing innovative approaches to drug design and delivery. 小分子 can be designed to engage biological targets by various modes of action and act both intracellularly and extracellularly. Their distribution can further be tailored to allow for systemic exposure with or without brain penetration. Click on the tiles below to read more about our research from traditional small molecules which have long been a cornerstone of our business, 以开创性的, 新的小分子方法，如PROTACs和环硅酸锆.

抗体疗法

抗体可以非常准确地靶向蛋白质，并且可以通过工程设计来提高特异性, 效力和亲和力. We are expanding the scope of our antibody engineering platforms and designing new and improved therapeutics 如 bispecific antibodies and fragment antibodies with an aim of accessing difficult-to-reach therapeutic targets. Learn more about our research efforts to create the next generation of antibody-based therapeutics by clicking on the tiles below.

肽或蛋白质疗法

通过澳门第一赌城在线娱乐在蛋白质工程方面的长期专业知识, 澳门第一赌城在线娱乐正在推进传统和新型的蛋白质和肽疗法. 因为蛋白质是大分子, they are generally not cell permeable and have traditionally been restricted to extracellular targets and injectable administration routes. 多肽是一种较小的蛋白质疗法. 它们通常发育得很小, 细胞外目标的特异性和高选择性配体.

通过各种合作, we are exploring the development of not only traditional protein therapeutics and peptides but also potentially innovative therapies 如 Anticalin®蛋白质 and bicyclic peptides. 点击下面的图片阅读更多关于这些新型药物模式的信息.

Nucleotide-based疗法 & 基因治疗

基因组学的最新进展已经带来了无数潜在的新药物靶点, 基于核苷酸的治疗方法有机会对疾病产生真正的影响. We are exploring a number of nucleotide-based modalities from oligonucleotides and RNA-based therapies to using CRISPR/Cas9 as a potential therapeutic tool. 点击下面的图片阅读更多关于这些新型药物模式的信息.